Aderbal da Silva Duarte Filho (Boa Nova, ) é um maestro, compositor, arranjador, violonista e professor de música brasileiro. Filho de uma família de músicos do sudoeste da Bahia, começou a sua formação musical na infância, ouvindo, Percepção Musical – método de sofejo baseado na MPB. Salvador: Boanova. Join Facebook to connect with Aderbal Duarte Bossa Nova and others you may know. Facebook Professor de Percepção Musical · Salvador, Bahia, Brazil. Bivariate analyses showed that the perception of more sleep disturbance and daytime Silva, Aderbal R T; Santos, Ana Cecília Feio; Farfel, Jose M; Grinberg, Lea T; .. Lamônica, Dionísia Aparecida Cusin; Ferraz, Plínio Marcos Duarte Pinto; Gagnon, Carl A.; Traesel, Carolina Kist; Music, Nedzad; Laroche, Jérôme;.
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Anti-obesity effect of intranasal administration of galanin-like peptide GALP in obese mice. Galanin-like peptide GALP has an anti-obesity effect in rats and mice. It has been reported that the uptake of GALP by the brain is higher after intranasal administration than with intravenous injection.
This study therefore aimed to clarify the effect of intranasal administration of GALP on the feeding behavior of lean and obese mice.
Autoradiography revealed the presence of I-GALP in the olfactory bulb and the brain microcirculation. These results suggest that intranasal administration is an effective route whereby GALP can exert its effect as an anti-obesity drug.
Absorption of clonazepam after intranasal and buccal administration. Serum concentrations of clonazepam after intranasalbuccal and intravenous administration were compared in a cross-over study in seven healthy male volunteers.
Each subject received a 1. A Cmax of 6.
A second peak 4. After buccal administration a Cmax of 6. Two minutes after i. It is concluded that intranasal clonazepam is an alternative to buccal administration. However, the Aderrbal of clonazepam after intranasal administration is not high enough to recommend the intranasal route as an alternative to intravenous injection.
To develop high bioavailability aderval without irritation for Panax notoginsenosides. The effects of some additives such as microcrystalline cellulose, beta-cyclodextrin and hydroxypropyl cellulose on drug in the preparations were examined.
Saponins of Panax aderba PNS was absorbed in rabbits more when administered intranasally than through duzrte routines, and the formulations including MCC both gave high bioavailability and low irritation.
Bioavailability of Panax notoginsenosides can be increased through changing routine of administration and formulations.
Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver duartf to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression.
It has been developed as vaccine carriers for the prevention of lifestyle disease such as obesity. Intranasal administration of therapeutics using nanogels for the management of brain diseases revealed that the drug transportation was via the olfactory nerve pathway resulting in rapid drug delivery to the brain with excellent neuroprotective effect. The application of nanogels as vaccine carriers also induced significant responses associated with protective immunity against selected bacterial and viral infections.
This review provides a detailed information on the enhanced therapeutic effects, mechanisms and biological efficacy of nanogels for intranasal administration. Microdialysis pharmacokinetic study of scopolamine in plasma, olfactory bulb and vestibule after intranasal administration.
The purpose of this study was to investigate the microdialysis pharmacokinetic of scopolamine in plasma, olfactory bulb and vestibule after intranasal administration. The pharmacokinetic study of subcutaneous and oral administration was also performed in rats.
From the in vivo results, scopolamine intranasal administration can avoid hepatic first-pass effect. Tmax plasma samples after intranasal administration were significantly faster than oral administration and subcutaneous injection. The relative bioavailability of intranasal administrations was Moreover, one can see that in comparison with scopolamine subcutaneous administrationscopolamine intranasal gel and solutions can increased drug target index DTI with olfactory bulb 1.
The results indicated that scopolamine can be absorbed directly through the olfactory mucosa into adrebal olfactory bulb, and then transported to various brain tissue after intranasal administrationwith the characteristics of brain drug delivery. Restricted sedation and absence of cognitive impairments after administration of intranasal scopolamine.
Space motion sickness in astronauts during spaceflight causes significant discomfort, which might impede their functionality.
Pharmacological treatment has been mainly restricted to promethazine. Transdermal and oral scopolamine have also been used in space; however, their use was reduced due to unpredictable effectiveness and side effects. Recently, intranasal scopolamine administration has gained much interest, since this route ensures fast and reliable absorption with a decreased incidence of undesirable side effects.
The aim adernal this study was to evaluate the effect of intranasal scopolamine on cognitive performance and to determine its side effects.
This double-blind, placebo controlled, repeated measures study evaluated vigilant attention, short-term memory, implicit memory and working memory.
Side effects were reported on a item questionnaire and sleepiness was assessed by the Karolinska, Stanford and Epworth Sleepiness Scales. Scopolamine had no effect on cognitive function. Only the Karolinska score was significantly increased for scopolamine compared to placebo. Participants reported a dry mouth and dizziness after receiving scopolamine. Results show that intranasal scopolamine did not impair cognitive performance. Intranasal scopolamine might be a good alternative to promethazine for the alleviation of space motion sickness, since the agent has minimal sedative effects and does not hamper cognitive darte.
Huntington’s disease HD is an autosomal dominant disease caused by an expansion of CAG repeats in the gene encoding for huntingtin. Brain metabolic dysfunction and altered Akt signaling pathways have been associated with disease progression. Upregulation of Akt following rhIGF-1 treatment occurred concomitantly with increased phosphorylation of mutant huntingtin muiscal Ser These data suggest that intranasal administration of rhIGF-1 ameliorates HD-associated glucose metabolic brain abnormalities and mice phenotype.
Intranasal administration of oxytocin: The intranasal IN- administration of substances is attracting attention from scientists as well as pharmaceutical companies.
The effects are surprisingly fast and specific. The present review explores our current knowledge about the routes of access to the cranial cavity. Among the IN-applied adderbal oxytocin OT has an extensive history.
Originally applied in women for its physiological effects related to lactation and parturition, over the last decade most studies focused on their behavioral ‘prosocial’ effects: Only very recently in a microdialysis study in rats and mice, the ‘direct-nose-brain-pathways’ of IN-OT have been investigated directly, implying that we are strongly dependent on results obtained aderba, other Psrcepo substances.
Especially the possibility that IN-OT activates the ‘intrinsic’ OT-system in the hypothalamus as well needs further clarification. We conclude that IN-OT administration may be a promising approach to influence human communication but that the existing lack of information about the neural and physiological mechanisms involved is a serious problem for the proper understanding and interpretation of the observed effects.
No effect of adjunctive, repeated dose intranasal insulin treatment on body metabolism in patients with schizophrenia. Objective This study examined the effect of adjunctive intranasal insulin therapy on body metabolism in patients with schizophrenia. Method Each subject had a DSM-IV diagnosis of schizophrenia or schizoaffective disorder and had been on stable dose of antipsychotic agent for at least one month.
repeated intranasal administration: Topics by
In an 8-week randomized, double-blind, placebo-controlled study, subjects received either intranasal insulin 40IU 4 times per day or placebo. The whole body dual-energy X-ray absorptiometry DXA was used to assess body composition.
Lipid particles were assessed using nuclear magnetic resonance NMR spectroscopy. All assessments were conducted at baseline, and repeated at week 8. Results A total number of 39 subjects completed the study 18 in the insulin group, 21 in the placebo group. Conclusion In the present study, adjunctive therapy of intranasal insulin did not seem to improve body metabolism in patients with schizophrenia.
The implications for mmusical studies were discussed.
cysticercosis clinical manifestations: Topics by
The last decade has witnessed a surge in studies on the clinical applications of intranasal oxytocin as a method of enhancing social interaction. However, the molecular and cellular mechanisms underlying its function are not completely understood. Since oxytocin is involved in the regulation of hypothalamic-pituitary-gonadal axis by affecting the gonadotropin-releasing hormone GNRH system, the present study addressed whether intranasal application of oxytocin has a role in affecting GNRH expression in the male rat hypothalamus.
In addition, we assessed expression of two excitatory kisspeptin and neurokinin B and two inhibitory dynorphin and RFamide-related peptide-3 neuropeptides upstream of GNRH neurons as a possible route to relay oxytocin information. The expression of neurokinin B was increased from the basal levels following the intervention. These observations are consistent with the hypothesis that applications of intranasal oxytocin can affect the GNRH system.
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration. The intranasal administration route is increasingly being used as a noninvasive method to bypass the blood-brain barrier because evidence suggests small fractions of nasally applied macromolecules may reach the brain directly via olfactory and trigeminal nerve components present in the nasal mucosa.
Upon reaching the olfactory bulb olfactory pathway or brainstem trigeminal pathwayintranasally delivered macromolecules appear to rapidly distribute within the brains of rodents and primates. The mechanisms responsible for this distribution have yet to be fully characterized.
Comparison of tracer plasma levels and fluorescent signal distribution associated with the PVS of surface arteries and internal cerebral vessels showed that the intranasal route results in unique central access to the PVS not observed after matched intravascular dosing in separate animals.
Intranasal targeting to the PVS was tracer size dependent and could be regulated by modifying nasal epithelial permeability. These results suggest cerebral perivascular convection likely has a key role in intranasal drug delivery to the brain.
Saliva oxytocin measures do not reflect peripheral plasma concentrations after intranasal oxytocin administration in men. Oxytocin plays an important role in social behavior. Thus, there has been significant research interest for the role of the oxytocin system in several psychiatric disorders, and the potential of intranasal oxytocin administration to treat social dysfunction.
Measurement of oxytocin concentrations in saliva are sometimes used to approximate peripheral levels of oxytocin; however, the validity of this approach is unclear. Additionally, we found that saliva oxytocin concentrations were not significantly associated with plasma oxytocin concentrations after either intranasal or intravenous oxytocin administration.
Altogether, we suggest that saliva oxytocin concentrations do not accurately index peripheral oxytocin after intranasal or intravenous nusical administrationat least in men. The data perxepo that elevated oxytocin saliva levels after nasal delivery primarily reflect exogenous administered oxytocin that is cleared from aderhal nasal cavity to the oropharynx, and is therefore a weak surrogate for peripheral blood measurements.
Postprandial administration of intranasal insulin intensifies satiety and reduces intake of palatable snacks in women. The role of brain insulin signaling in the control of food intake in humans has not been thoroughly defined. We hypothesized that the hormone contributes to the postprandial regulation of appetite for palatable food, and assessed the effects on appetite and snack intake of postprandial versus fasted intranasal insulin administration to the brain in healthy women.
Two groups of subjects were intranasally administered IU insulin or vehicle after lunch. Dharte hours later, consumption of cookies duzrte varying palatability was measured under the pretext of a taste test. In a control study, the durte of intranasal insulin administered to fasted female subjects were assessed. Compared with placebo, insulin administration in the postprandial but not in the fasted state decreased appetite as well as intake and rated palatability of chocolate chip cookies the most palatable snack offered.
In both experiments, intranasal insulin induced a slight decrease in plasma glucose but did not affect serum insulin concentrations. Data indicate that brain insulin acts as a relevant satiety signal during the postprandial period, in particular reducing the intake of highly palatable food, and impacts peripheral glucose homeostasis. Postprandial intranasal insulin administration might be useful in curtailing overconsumption of snacks with accentuated rewarding value.