Evolución de la leucemia linfoblástica aguda en la edad pediátrica en 29 años ( )Outcome of acute lymphoblastic leukemia in the pediatric age group . La leucemia linfoblástica aguda (LLA) es el cáncer más común en los niños y está entre los más curables de las malignidades pediátricas. El análisis citogenético de las células blásticas en niños con leucemia linfoblástica aguda (LLA) ha permitido el reconocimiento de alteraciones cromosómicas.
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Cytogenetic analysis of blast cells in childhood acute lymphoblastic leukemia has led to the recognition of specific non-random chromosomal abnormalities with prognostic value. Most patients with ALL show karyotype abnormalities, either in chromosome number ploidy or as structural changes such as translocations, inversions, or deletions.
Many of these chromosomal alterations are associated with specific cytomorphological and immunological types.
Ilnfoblastica greatest impact on patient management has been the finding that the cytogenetic result is an independent prognostic indicator. Certain atuda are associated with a favorable prognosis while others indicate a poor outcome. This has led to the administration of alternative therapies according to risk. This study focuses on the most important chromosomal abnormalities found linfoblastiva childhood ALL and their prognostic and therapeutic implications.
Cytogenetic abnormalities in acute lymphoblastic leukemia. Hospital 12 de Octubre Edificio Materno-Infantil. Hospital 12 de Octubre. This study focuses on the most important chromosomal abnormalities found in childhood ALL and their prognostic and therapeutic implications. Current status of cytogenetic research in childhood acute lymphoblastic leukemia.
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Leucemia linfoblástica aguda en pacientes portadores de síndrome de Down
Blood, 79pp. Hyperdiploid acute lymphoblastic leukemia in children.
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Factores de riesgo para la leucemia linfocítica aguda
Collaborative study of karyotypes in childhood acute lymphoblastic leukemia. Leukemia, 7pp. Ziemin-Van der Poel, N. Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias. Human acute leukemia cell line with the t 4;11 chromosomal rearrangement exhibits Linfovlastica lineage and monocytic characteristics. Blood, 65pp. Unifirm approch to risk classification and treatment assignment to children with acute lymphoblastic leukemia.
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Factores de riesgo para la leucemia linfocítica aguda
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